Abstract
A novel and simple HPTLC method has been developed for the estimation of Cefadroxil (CFD) in bulk and pharmaceutical dosage form on silica gel precoated aluminum 60F254 plates, (10 cm x10 cm) with 0.25 mm thickness. The separation was carried out using ethyl acetate: chloroform (8:2v/v) as mobile phase. The Chromatographic scanning was carried out at 254 nm. The Rf (± SD) values were found to be 0.38 ± 0.05 for CFD. The linearity for analyte was in the range 100-500 ng/band for CFD with correlation coefficients, r2 = 0.9996. The percentage recovery obtained for CFD was in the range of 99.28-100.13% respectively. The proposed method was optimized and validated as per the ICH guidelines17. Â
Highlights
IntroductionCefadroxil is a semi-synthetic first generation oral cephalosporin drug effective against gram-positive and gram-negative bacterial infections and similar to cephalexin and cephradine in structure and spectrum of antibacterial activity
Cefadroxil is a semi-synthetic first generation oral cephalosporin drug effective against gram-positive and gram-negative bacterial infections and similar to cephalexin and cephradine in structure and spectrum of antibacterial activity1. It is used in the treatment of mild to moderate infections of the respiratory and urinary tracts, skin and soft tissue infections
It has been used in the prophylaxis of recurrent urinary tract infections in children
Summary
Cefadroxil is a semi-synthetic first generation oral cephalosporin drug effective against gram-positive and gram-negative bacterial infections and similar to cephalexin and cephradine in structure and spectrum of antibacterial activity. Cefadroxil is a semi-synthetic first generation oral cephalosporin drug effective against gram-positive and gram-negative bacterial infections and similar to cephalexin and cephradine in structure and spectrum of antibacterial activity1 It is used in the treatment of mild to moderate infections of the respiratory and urinary tracts, skin and soft tissue infections. The chemical name of Cefadroxil is (6R, 7R)-7-[(2R)-2-(4-hydrophenyl) acetamido]-3-methyl-8-OXO5-thia-1- azabicycio [4.2.0] oct-2-ene-2-carboxylic acid hydrate. It has a molecular formula of C16H17N3O5S and molecular weight of 363.38g/mol.
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