Abstract
Ribonucleic acid-binding proteins (RBPs) are reportedly involved in tumor progression and recurrence; however, the functions and mechanisms of action of RBPs in ovarian serous cystadenocarcinoma (OSC) are not known. To address these issues, gene expression profiles of OSC tissues from The Cancer Genome Atlas (TCGA) and normal tissues from the Genotype-Tissue Expression database were compared in order to identify RBPs that are differentially expressed in OSC. We also analyzed the biological functions of these RBPs and their relationship to clinical outcome. There were 190 RBPs that were differentially expressed between OSC and normal tissues, including 93 that were upregulated and 97 that were downregulated. Five of the RBPs were used to construct a prediction model that was evaluated by univariate and multivariate Cox regression analyses. TCGA data were randomly divided into training and test cohorts, and further categorized into high- and low-risk groups according to risk score in the model. The overall survival (OS) of the high-risk group was shorter than that of the low-risk group (training cohort P = 0.0007596; test cohort P = 0.002219). The area under the receiver operating characteristic curve of the training and test cohorts was 0.701 and 0.638, respectively, demonstrating that the model had good predictive power. A nomogram was established to quantitatively describe the relationship between the five prognostic RBPs and OS in OSC, which can be useful for developing individualized management strategies for patients.
Highlights
Ovarian cancer, a common gynecologic cancer, accounts for just 3% of newly diagnosed tumors but is the fifth leading cause of cancer-related deaths in women; this is partly attributable to the difficulty of early diagnosis and high rates of metastasis and recurrence (Li et al, 2012; Xiong et al, 2018)
Mutations in the genes encoding the Ribonucleic acid-binding proteins (RBPs) Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) have been linked to the pathogenesis of amyotrophic lateral sclerosis, and the proteins were depleted from the nucleus and aggregated in the cytoplasm in affected neurons (Brinegar and Cooper, 2016)
Ribonucleic acid profiles of tumor tissue from ovarian serous cystadenocarcinoma (OSC) patients and normal tissues were obtained from The Cancer Genome Atlas (TCGA) database
Summary
A common gynecologic cancer, accounts for just 3% of newly diagnosed tumors but is the fifth leading cause of cancer-related deaths in women; this is partly attributable to the difficulty of early diagnosis and high rates of metastasis and recurrence (Li et al, 2012; Xiong et al, 2018). Mutations in the genes encoding the RBPs Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) have been linked to the pathogenesis of amyotrophic lateral sclerosis, and the proteins were depleted from the nucleus and aggregated in the cytoplasm in affected neurons (Brinegar and Cooper, 2016). The RBPs Elavlike family (CELF) and Muscleblind-like (MBNL) contribute to the pathogenesis of myotonic dystrophy by reverting to fetal expression patterns and promoting fetal mRNA processing in adult tissues (Brinegar and Cooper, 2016)
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