Abstract
A simple, accurate, precise, and rapid UV spectrophotometric method was developed for simultaneous estimation of Etoricoxib and Thiocolchicoside in the tablet dosage form. Etoricoxib showed maximum absorbance at 270 nm, while Thiocolchicoside showed maximum absorbance at 260 nm. These two wavelengths were selected for further analysis. The developed method was validated as ICH guidelines including parameters as linearity, range, precision, LOD, LOQ, and accuracy. The absorbance range for Etoricoxib (5-30 µg/ml) was found to be 0.210-0.799. These aliquots obeyed Beer-Lambert’s law with regression of 0.995. The absorbance range of Thiocolchicoside (5-30 µg/ml) was found to be 0.147-0.468 with a regression of 0.998. The method of precision (interday, intraday) was found within limits (RSD>2). The % recovery was found to be within the range. As per the ICH Q2 R1 guideline, the result was validated statistically and was found to be satisfactory.
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