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Abstract
Development and Validation of a Stability-indicating HPLC-UV Method for the Simultaneous Determination of Flurbiprofen and Triclosan in Dental Nanogel Formulations
Highlights
Modern medicine is gradually changing its approach with an increased focus on drug combination therapy in recent years
The proposed high performance liquid chromatography (HPLC) method was validated according to ICH guidelines and the validation characteristics such as system suitability, linearity, range, accuracy, precision, specificity, limit of detection (LOD) and limit of quantification (LOQ) were assessed.[8]
Accuracy and precision were calculated as percentage (%) recovery and percentage RSD of the NGs and quality control (QC) sample solutions, and the results indicated satisfactory recoveries for both drugs
Summary
Modern medicine is gradually changing its approach with an increased focus on drug combination therapy in recent years. Many clinicians and other health practitioners are suggesting combination therapy for a lot of disorders because of its ability to achieve synergistic therapeutic effects, hit multiple targets, decrease toxicity, minimise drug resistance, and improve the therapeutic profile.[1] Dentistry is not left out in this pace of development as there are various drug combination therapies that have proved promising for the treatment of dental diseases.[2,3] Advances in nanotechnology-based delivery systems such as nanoparticles (NPs) and nanogels (NGs) have enabled more efficient delivery of a myriad of drugs to the desired site of action.[3] A suitable formulation of FLB (analgesic, anti-inflammatory) and TCS (broad-spectrum antimicrobial) combination would be highly desirable for periodontal therapy, owing to the therapeutic efficacy of the drugs. There are reported methods for the estimation of FLB and TCS in their separate forms, a suitable validated stability indicating analytical method for the simultaneous quantification of these drugs is still lacking.[4,5] this study was undertaken to develop and validate a stability-indicating high performance liquid chromatography-ultraviolet (HPLC-UV) method for the simultaneous determination of FLB and TCS in NG formulations
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