Abstract
The worldwide global increase in serum 25-hydroxyvitamin D (25(OH)D) measurements has led some countries to restrict reimbursement for certain clinical situations only. Another approach could consist in providing physicians with screening tools in order to better target blood test prescription. The objective of the SCOPYD study was to identify the best combination of predictors of serum VitD concentration among adults aged 18–70 years. Potential risk factors for VitD deficiency were collected using a comprehensive self-administered questionnaire. A multivariable linear regression was used to build a predictive model of serum 25(OH)D concentration. Among 2488 participants, 1080 (43.4%) had VitD deficiency (<50 nmol/L) and 195 (7.8%) had severe deficiency (<25 nmol/L). The final model included sunlight exposure in the preceding week and during the last holidays, month of blood sampling, age, sex, body mass index, skin phototype, employment, smoking, sport practice, latitude, and VitD supplementation in preceding year. The area under the curve was 0.82 (95% CI (0.78; 0.85)) for severe deficiency. The model predicted severe deficiency with a sensitivity of 77.9% (95% CI (69.1; 85.7)) and a specificity of 68.3% (95% CI (64.8; 71.9)). We identified a set of predictors of severe VitD deficiency that are easy to collect in routine that may help to better target patients for serum 25(OH)D concentration determination.
Highlights
Vitamin D deficiency has long been recognized as a cause of osteomalacia in adults and rickets in children
Other exclusion criteria were current or recent participation in a study related to vitamin D, pregnancy, or breast-feeding, ongoing antiepileptic or antiretroviral treatment, ongoing long-term glucocorticoid treatment
A total of 2591 participants were enrolled in the study
Summary
Vitamin D deficiency has long been recognized as a cause of osteomalacia in adults and rickets in children. Many observational studies have found that serum vitamin D concentration was inversely correlated with the occurrence of multiple chronic disorders (e.g., cancer, cardiovascular disease, diabetes, and autoimmune disorders). Due to this growing interest in the pleiotropic putative effects of vitamin D, a massive increase in the number of serum 25-hydroxyvitamin D (25(OH)D) measurements has been observed worldwide [2,3,4,5,6]. In this context, providing physicians with clinical tools to identify and discriminate between high-risk patients and those presenting a very low risk of vitamin D deficiency should help them to better target the patients for whom vitamin D concentration determination is indicated.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
