Abstract
For the registration of phytomedicines and their availability to the population, National Agency of Sanitary Surveillance (ANVISA) establishes quality, security, and efficacy parameters, stipulating control requirements similar to those applied to synthetic medicines. This work reports the investigation of the bark of Himatanthus lancifolius and its extracts aiming to contribute to the standardization of derivatives of this plant species. The developed quantification method shows high selectivity at 281nm, which confers confidence to the detection of the alkaloids. The method is robust, according to the current regulation, and shows linearity, precision, and accuracy, beside accessibility and simplicity in execute. The pH 10 alkaloid fraction obtained from the aqueous extract of the analyzed sample represents 0.219% in the dried extract. These results contribute for reducing the lack of methods for the quality control of phytomedicines prepared from H. lancifolius.
Highlights
Apocynaceae include about 450 genus and 4,950 species with pantropical distribution which, in Brazil, are represented by three subfamilies: Asclepiadoideae, Rauvolfioideae, and Apocynoideae [1]
According to the Brazilian regulation on phytomedicines herbal materials can be standardised on the basis of a metabolic class, a specific group of substances, which here is a pH 10 alkaloid fraction aiming to guarantee the chemical homogeneity of each batch of the herbal product [6, 7]
Brazilian Agricultural Research Corporation (EMBRAPA) provided the plant material collected in the morning
Summary
Apocynaceae include about 450 genus and 4,950 species with pantropical distribution which, in Brazil, are represented by three subfamilies: Asclepiadoideae, Rauvolfioideae, and Apocynoideae [1]. They occur in grassland and forest including about 60 genus and 750 species [2]. Carl Willdenow and Josef Schultes described genus Himatanthus, and it includes only 13 species, all of them found in South America, mainly in Amazonia [4] This genus was erroneously referred to as Plumeria up to 1938 when Woodson Jr. in “Studies in the Apocynaceae: an evaluation of the genera Plumeria L. and Himatanthus Willd.” reported that the aboriginal Himatanthus species from South. According to the Brazilian regulation on phytomedicines herbal materials can be standardised on the basis of a metabolic class, a specific group of substances, which here is a pH 10 alkaloid fraction aiming to guarantee the chemical homogeneity of each batch of the herbal product [6, 7]
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