Abstract
The mouse has been used almost exclusively as the experimental animal for host resistance studies in the United States. Host resistance models in mice have been validated and these types of studies are an integral part of the National Toxicology Program's (NTP) immunotoxicology testing program. Given that the Fischer 344 rat is the animal of choice for the NTP's toxicology studies, it was desirable to develop host resistance assays in this rat strain, eliminating the need to extrapolate doses between mouse and rat models. These studies were aimed at the development and the validation of a host resistance model to Listeria monocytogenes, a gram-positive, facultative intracellular bacterium, in the Fischer 344 rat. The results demonstrated that L. monocytogenes infection in the Fischer 344 rat produces a very similar disease with respect to onset and duration as in the mouse. Animals inoculated with up to 3 105 viable colony forming units (CFU) of L. monocytogenes were capable of resisting overt disease whe...
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