Abstract
BackgroundThe breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from those with two copies of the Ridge allele.ResultsA quantitative PCR test was developed and dogs of known genotype were used as test subjects. In all cases, the correct genotype was determined experimentally.ConclusionsThis work provides a rapid and accurate methodology for determining dog genotype with respect to the Ridge allele.
Highlights
The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18
A DNA test has been developed and dogs of known genotype were used as test subjects
Previous work [2] indicated that the ridge trait is inherited in a dominant fashion; a single copy of this duplication results in appearance of a ridge, and dogs with two copies of the duplication are indistinguishable from dogs with one copy. We refer to this duplication as the Ridge allele
Summary
The breed-defining dorsal ridge in Rhodesian Ridgeback dogs is the result of a 133,000 base pair duplication on chromosome 18. Because this trait is dominant, heterozygous dogs cannot be discriminated from those with two copies of the Ridge allele. Previous work [2] indicated that the ridge trait is inherited in a dominant fashion; a single copy of this duplication results in appearance of a ridge, and dogs with two copies of the duplication are indistinguishable from dogs with one copy. We refer to this duplication as the Ridge allele.
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