Abstract
Most of the pharmaceutical and cosmetic products used for the treatment of dandruff have zinc pyrithione as an active ingredient; therefore; quantifying this component becomes necessary. The purpose of this study was the validation of two simple and fast methodologies in the quantification of zinc pyrithione for shampoo quality control to guarantee consumer safety. The first method comprised a manual complexometric titration, and the second comprised a potentiometric titration performed with an automatic titrator, obtaining sensitivity values of 0.0534% and 0.0038%, respectively, precision expressed in RSD% values below than 1%, and accuracy in recovery percentage greater than 99%. Additionally, both methods were robust when subjected to significant changes in working conditions (temperature and pH) and were selective even in the presence of interferences and degradation products. Finally, the methodologies were adequate to ensure the quality of shampoo to ensure the safety of consumers.
Highlights
Zinc pyrithione (ZnPT) is an organometallic compound with chemical formula C10H8N2O2S2Zn that has bactericidal and fungicidal activity
E most common factor is imbalance in the microbial biome due to the increase in microorganisms of the Malassezia genus whose metabolic cycle involves the degradation of fatty acids, generating irritation and hyperflorative activity of the epidermis [3,4,5,6]
Selectivity. e response obtained for solvent blank and placebo was the same, as well as for critical sample and enriched placebo, confirming that the components of the matrix did not interfere in the analysis. e shampoo sample under photolytic and thermolytic conditions did not produce reactions that could interfere with the ZnPT
Summary
Zinc pyrithione (ZnPT) is an organometallic compound with chemical formula C10H8N2O2S2Zn that has bactericidal and fungicidal activity. It is the antifungal agent most used in shampoos for control of dandruff due to its versatility. E most common factor is imbalance in the microbial biome due to the increase in microorganisms of the Malassezia genus whose metabolic cycle involves the degradation of fatty acids, generating irritation and hyperflorative activity of the epidermis [3,4,5,6]. ZnPT depolarizes the microorganism membrane, preventing the transport of nutrients and energy production [9, 10], and can increase the amount of copper present in the cell, diminishing the functions of ironsulfur proteins [11, 12]. In addition to antifungal properties to combat dandruff, ZnPT acts at the cellular level by being cytostatic, regulating the uncontrolled division of scalp cells, and is antiseborrheic due to the sulfur groups in the molecule [13, 14]
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