Abstract
Development and Therapeutic Potential of Foot-and-Mouth Disease Virus Specific Anti-Idiotype Antibodies
Highlights
Foot-and-mouth disease (FMD) is an endemic highly contagious disease in most parts of the world that affects broad host range including domestic and wild cloven-footed animals (Smith et al, 2004)
Results were further confirmed via Enzyme-linked immunosorbent assay (ELISA) test for three serotypes (Asia-1, A, and O) of FMD virus
Group GA1 exhibited ELISA titer ranging from 86 % to 93 % while mean inhibition titer of 91 % was attained on day 21 PI followed by a slow decrease to 90 % and 89 % on days 28 and 35, respectively
Summary
Foot-and-mouth disease (FMD) is an endemic highly contagious disease in most parts of the world that affects broad host range including domestic and wild cloven-footed animals (Smith et al, 2004). An economic burden of six to twenty billion US dollars is associated with the FMD in terms of animal milk and meat production, mortality, preventive measures, and trade restrictions (Knight-Jones and Rushton, 2013). FMD virus, a positive-sense single-stranded RNA virus is responsible for the disease outbreaks. The virus has seven major serotypes each having subtypes. There is no cross-protection between the serotypes (Waters et al, 2018). Different disease control policies have been adopted across the globe including restriction of animal movement and mass vaccination programs ( Jamal and Belsham, 2013). Vaccination is considered an effective strategy to control the disease, but still, there are some uncertainties in the time of vaccination and type of vaccines. FMD virus is RNA virus, the genetic
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