Abstract
BackgroundSurvivors of childhood acute lymphoblastic leukemia (cALL) experience cardiometabolic and bone complications after treatments. This study aimed at developing and validating an interview-administrated food frequency questionnaire (FFQ) that will serve to estimate the impact of nutrition in the development of long-term sequalea of French-Canadian cALL survivors.MethodsThe FFQ was developed to assess habitual diet, Mediterranean diet score, nutrients promoting bone health and antioxidants. It was validated using a 3-day food record (3-DFR) in 80 cALL survivors (50% male) aged between 11.4 and 40.1 years (median of 18.0 years). Reproducibility was evaluated by comparing FFQs from visit 1 and 2 in 29 cALL survivors.ResultsWhen compared to 3-DFR, the mean values for macro- and micronutrient intake were overestimated by our FFQ with the exception of lipid-related nutrients. Correlations between nutrient intakes derived from the FFQs and the 3-DFRs showed moderate to very good correlations (0.46–0.74). Intraclass correlation coefficients assessing FFQ reproducibility ranged from 0.62 to 0.92, indicating moderate to good reliability. Furthermore, classification into quartiles showed more than 75% of macro- and micronutrients derived from FFQs 1 and 2 classified into the same or adjacent quartile.ConclusionsOverall, our results support the reproducibility and accuracy of the developed FFQ to appropriately classify individuals according to their dietary intake. This validated tool will be valuable for future studies analyzing the impact of nutrition on cardiometabolic and bone complications in French-speaking populations.
Highlights
Survivors of childhood acute lymphoblastic leukemia experience cardiometabolic and bone complications after treatments
Study design The study design includes 3 phases (Fig. 1): the first consists in the 5-step development of the food frequency questionnaire (FFQ); the second reflects the validation of the questionnaire in a cohort of 80 participants; and the third tests the reproducibility of the tool by comparing FFQs collected during 2 different visits
We evaluated the time difference between the administration of the FFQ and the completion of the 3-day food record (3-DFR)
Summary
Survivors of childhood acute lymphoblastic leukemia (cALL) experience cardiometabolic and bone complications after treatments. Inadequate nutrition has been associated with an increased risk of developing long-term sequelae in cALL survivors [9,10,11], while the inclusion of specific nutrients or dietary patterns was found protective [10, 11]. Key nutrients for bone health include proteins, Morel et al Nutrition Journal (2018) 17:45 calcium and vitamin D [12] In addition to their antiinflammatory actions [13, 14], antioxidants (polyphenols, vitamins and minerals: e.g. vitamins A, C, E and selenium) mainly found in plant foods and whole grains can improve blood pressure and lipid profile [14,15,16]. Food scores have been developed to evaluate the adherence to Mediterranean diet and are mainly used in nutritional epidemiologic studies [17]. The cardio protective properties of a Mediterranean dietary pattern have been widely reviewed [18,19,20]
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