Abstract
Acetylcholine is released from parasympathetic nerve terminals and binds to muscarinic acetylcholine (mACh) receptors to elicit negative chronotropic and inotropic effects on the heart. The molecular mechanisms for these cardiac effects are not well understood. Investigation of the mACh receptor has been greatly facilitated by the development of the potent cholinergic antagonist [3H] quinuclidinyl benzilate (QNB) which binds specifically and with high affinity to the mACh receptor (1). [3H]QNB can be used to study the interaction of agonists and antagonists with the receptor and quantitate the number of receptors present in cells and tissues.
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