Abstract
The author studied the changes that occur in the spermatic tract of rabbits during and after the administration of hexestrol. Under the influence of hexestrol administration lasting for from 3 to 311 days, atrophy of the epithelium occurs along with partial collapse of various portions of the duct system, as well as edem and moderate cellular infiltration of the distal portion of the duct system. Metaplasia of the epithelium into the stratified squamous type, with atypical keratinization, was observed in the distal portion of the ductus epididymidis in 5 out of 41 animals; in one rabbit the ampulla of the vas deferens was also involved. From two to seven months after the cessation of hexestrol administration (which was continued for three montns in this group) a slow restoration of specific differentiation occurred. The dependence of atrophic and regenerative changes in the vas deferens on similar changes in the testes is emphasized.
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