Abstract
BackgroundDermatological disease significantly affects patient’s health-related quality of life (HrQoL). Skindex is one of the most frequently used dermatology-specific HrQoL measures. Currently no Chinese version of Skindex is available. The aim of this study was to translate and culturally adapt Skindex-29 and Skindex-16 into Chinese, and to evaluate their reliability and validity.MethodsTranslation and cultural adaption were performed following guidelines for cross-cultural adaption of health-related quality of life measures. Subsequently, a cross-sectional study was conducted in which patients with dermatological disease (n = 225) were enrolled. The Chinese version of Skindex-29 and Skindex-16 and Dermatology Life Quality Index (DLQI) were completed. Reliability was evaluated with internal consistency using Cronbach’s alpha. Validity was evaluated using known-groups validity, convergent validity and factor structure validity.ResultsThere were both seven items of Skindex-29 and Skindex-16 requiring a second forward- and backward- translation to achieve the final satisfactory Chinese version. The internal consistency reliability was high (range of Cronbach’s alpha for the scales of Skindex-29 0.85-0.97, Skindex-16 0.86-0.96). Known-group validity was demonstrated by higher scores from patients with inflammatory dermatosis than from patients with isolated skin lesions (P < 0.05). Evidence of factor structure validity of the Skindex-29 and Skindex-16 was demonstrated by both exploratory factor analysis that accounted for 68.66% and 77.78% of the total variance, respectively, and confirmatory factor analysis with acceptable fitness into the expected three-factor structure.ConclusionThis study has developed semantically equivalent translations of Skindex-29 and Skindex-16 into Chinese. The evaluation of the instruments’ psychometric properties shows they have substantial evidence of reliability and validity for use as HrQoL instruments in Chinese patients with dermatological disease.
Highlights
Dermatological disease significantly affects patient’s health-related quality of life (HrQoL)
In this study, we translated Skindex-29 and Skindex-16 into Chinese according to accepted steps in the generation of conceptually and linguistically equivalent translations of quality of life measures
Our results showed that the Chinese version of Skindex29 and Skindex-16 had good capacity to discriminate patients with inflammatory dermatosis and patients with isolated lesions, which was consistent with the original version and other language versions [17-20]
Summary
Dermatological disease significantly affects patient’s health-related quality of life (HrQoL). Skindex is one of the most frequently used dermatology-specific HrQoL measures. No Chinese version of Skindex is available. The aim of this study was to translate and culturally adapt Skindex-29 and Skindex-16 into Chinese, and to evaluate their reliability and validity. Health-related quality of life (HrQoL) in dermatological patients has received growing recognition as measuring the burden of skin disease on patients in the fields of clinical practice, clinical trial, and healthcare management. HrQoL of dermatological patients, and one of the main reasons is a lack of suitable instruments in Chinese that have been developed or adapted according to established scientific attributes and criteria [1]. Skindex is one of the best dermatological instruments to measure dermatology-specific HrQoL [2]. Skindex-29 was recommended as one of the instruments of choice in dermatology [7], and Skindex-16 was recognized as an accurate and
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