Abstract
Neisseria meningitidis (Nm) is a major cause of epidemic cerebrospinal meningitis and septicemia with high fatality rates.Effective polysaccharide vaccines and conjugate vaccines have been developed to control the infections caused by groups A,C,W135 and Y Nm,but there are no commonly used,effective vaccines against group B Nm (MenB) except that several outer membrane vesicles based vaccines are effective in certain areas.Current vaccine strategies are focused on outer membrane proteins.This paper reviews the progress in development of MenB vaccines and some key points of preclinical evaluation. Key words: Neisseria meningitidis, serogroup B ; Vaccines ; Bacterial outer membrane proteins
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