Abstract
Objective: Objective of the present research work was to prepare orodispersible tablets of carvedilol (CDL) for dysphagic patients.Methods: Carvedilol, an anti-hypertensive drug, was chosen as a model drug in this study. Orodispersible tablets of carvedilol were prepared using different super-disintegrating agents such as crospovidone, croscarmellose sodium and sodium starch glycolate at different concentrations. The best formulation was selected based on disintegration and dissolution profile that was further taken for sublimation studies using camphor, menthol and thymol. Drug-excipients interaction studies were carried out by fourier transform infra-red (FTIR) spectrophotometer with pure drug sample and optimized formulation.Results: The orodispersible tablet formulation having 4% croscarmellose sodium disintegrated in 92 sec. Hence this formulation was considered best formulation and taken further for sublimation studies. A formulation containing 10% w/w of menthol showed disintegration time of 16 sec with more than 96.64% drug release within 15 min. Menthol leaves the porous structure as it sublimates from the tablet. This might have contributed to the decrease in disintegration time. Hence, this formulation was considered optimized.Conclusion: From this study, it can be concluded that orodispersible tablets of carvedilol may prove to be more efficacious in the treatment of hypertension particularly in dysphagic patients.
Highlights
Dysphagia is a biomechanical disorder considered as a clinical syndrome
From many reported studies it has been estimated that over six million adults have dysphagia [1]. It can occur in all age groups, but the prevalence increases with increase in age [1, 3]
Crospovidone (CP), croscarmellose sodium (CCS), sodium starch glycolate (SSG), microcrystalline cellulose (MCC) and mannitol were purchased from SD fine chemicals ltd, Mumbai, India
Summary
Dysphagia is a biomechanical disorder considered as a clinical syndrome It is defined as "an inability to swallow, or a sensation that solids or liquids do not pass from the mouth to the stomach" [1, 3]. Other categories that experience problems using conventional dosage forms include are mentally ill, uncooperative and nauseated patients, those with condition of motion sickness, sudden episodes of allergic attack or coughing [2]. Oral conventional formulations such as tablets, capsules and liquids pose difficulty in swallowing, especially in dysphasic patients [3]
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