Abstract
The objective of the present study is to develop floating sustained release tablet of Rebamipide for the treatment of drug induced gastric ulcer using the force of buoyancy to remain in stomach and/or Upper part of GIT for prolonged period of time for getting local action. The floating sustained release tablets of Rebamipide were prepared by direct compression method using various polymers like HPMC K100M, PEO WSR-301, sodium bicarbonate, citric acid, PVP K30, dibasic calcium phosphate and talc. Sodium bicarbonate was used as a floating effervescent agent. After preliminary screening, the floating sustained release tablets were prepared using 32 full factorial design taking HPMC K100M and PEO WSR-301 as two independent variables, and the formulation batches were evaluated for all pre-compression and post-compression parameters. The study is focused on swelling index, floating lag time, total floating Time and % CDR. From batches suggested by the design, formulation batch F8 was selected and studied extensively for release kinetic, mechanism and stability studies.
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