Abstract
Abstract : The overall objective of this project is to implement a dual-modality single photon emission computed tomography (SPECT) and x-ray computed mammotomography (CmT) system for the detection and staging of breast cancer monitoring of treatment therapies and improving surgical biopsy guidance. The sequential acquisition with emission (nuclear) and transmission (x-ray) 3D imaging systems can aid in localizing the radioactive uptake of a tumor from the emission image by using the anatomical structure from the transmission image. In the first year both systems were integrated onto a single platform with a customized patient bed to allow emission and transmission imaging of a pendant uncompressed breast during a single session. Further investigation was done to ensure that each system was positioned such that it could fit over the patient bed and completely sample the breast. Physical constraints of each system were examined. A data acquisition sequence was designed for SPECT and CmT. Imaging feasibility with geometric phantoms and breast phantoms were performed to study the resolution/sampling properties and fusion of functional-anatomical images. One hybrid patient study was also carried out. In the next two years of this grant corrections due to the CmT offset geometry x-ray scatter and attenuation will be applied to increase contrast decrease noise and improve quantitative accuracy in the images. In addition to research clinical experience in other areas of breast cancer detection was explored.
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