Development and Optimisation of Mucoadhesive Films for Enhanced Drug Delivery in Treatment of Lichen Planus

Manima Maharjan,B.V.S Anusha,Sabina Sankhi,Sujit Shrestha,Beny Baby,Nirmal Raj Marasine

doi:10.3126/njhs.v1i1.38724

Abstract

Introduction: Mucoadhesive buccal films are most recently developed and preferred over buccal tablet because of the flexibility, better bioavailability, cost effectiveness, and good patient compliance it offers Objective: The study aimed to formulate mucoadhesive films of Clobetasol Propionate with reduced side effects, controlled release and better patient compliance, suitable for the management of oral lichen planus. Methods: Clobetasol Propionate Buccal Films were prepared by the incorporation of the Clobetasol Propionate along with polymers like Hydroxy Propyl Methyl Cellulose (HPMC) K4M, polyethylene glycol 400 and glycerol by solvent casting method. Results: The drug content of all the formulations was found to be 85.04% to 93.14%. The swelling index of all formulations of Clobetasol Propionate mucoadhesive buccal film was found to be 82% to 94.07%. Formulation F14 which contains Hydroxy Propyl Methyl Cellulose K4M (1%), and polyethylene glycol 400 (1%) exhibited better results compared to other combination of polymers in different concentration. It showed swelling index of 94.07%. Drug content was found to be 91% and showed release of drug up to 95.05% in 12 hours. The optimised formula showed no significant changes on stability studies when stored at 40ºC/75% RH for three months. Conclusions: The application of mucoadhesive buccal film containing Clobetasol Propionate appeared to be effective, avoiding the side effects and the data obtained in the study suggested that buccal films can be successfully designed to give controlled drug delivery.

Highlights

Mucoadhesive buccal films are most recently developed and preferred over buccal tablet because it offers flexibility, better bioavailability, cost effectiveness, and good patient compliance.[1,2] Films employs a water dissolving polymer that allows the dosage form to quickly hydrate, adhere and dissolve when placed on the tongue or in the oral cavity resulting in systemic drug delivery.[1]
The application of mucoadhesive buccal film containing Clobetasol Propionate appeared to be effective, avoiding the side effects and the data obtained in the study suggested that buccal films can be successfully designed to give controlled drug delivery
From this study it is concluded that the Clobetasol-17 Propionate can be formulation in mucoadhesive buccal films

Summary

Introduction

Mucoadhesive buccal films are most recently developed and preferred over buccal tablet because it offers flexibility, better bioavailability, cost effectiveness, and good patient compliance.[1,2] Films employs a water dissolving polymer that allows the dosage form to quickly hydrate, adhere and dissolve when placed on the tongue or in the oral cavity resulting in systemic drug delivery.[1] Oral lichen planus (OLP), a Citation: Maharjan M, Baby B, Sankhi S, Anusha B.V.S, Shrestha. Development and optimisation of mucoadhesive films for enhanced drug delivery in treatment of lichen planus. @2021 NJHS | Published by Madan Bhandari Academy of Health Sciences chronic autoimmune mucocutaneous inflammatory disease, affects the mucosal lining of the oral cavity causing white striations, papules or plaque with or without erythema and ulceration.[3] It affects 1-3% of the world’s population by triggering cytotoxic CD8+ T-cells causing apoptosis of the basal cells of the oral epithelium.[3,4]

Methods

Results

Conclusion