Abstract
A specific and sensitive radioimmunoassay has been developed to monitor plasma levels of captopril, the first orally active angiotensin-converting enzyme inhibitor. Because of the reactive nature of the captopril thiol group, captopril was measured as the captopril- N-ethylmaleimide complex (captopril-NEM). Accuracy studies, using samples with known added concentrations of captopril, were satisfactory ( r = 0.95, p < 0.001, y = 0.97, x − 2.02), and the radioimmunoassay results compared well with those determined by a gas chromatography/mass spectrometric method ( r = 0.98, p < 0.0005, y = 1.2, x − 19). The minimum detection limit of the assay was 2 μg captopril/litre plasma.
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