Development and in-vitro evaluation of mucoadhesive gastroretentive matrix tablets of cephalexin

Abstract

Cephalexin is a semi-synthetic cephalosporin β-lactum antibiotic intended for oral administration used to treat urinary tract infections, respiratory tract infections, skin and soft tissue infections. The present investigation concerns the development and evaluation of single unit mucoadhesive drug delivery system of cephalexin. Mucoadhesive drug delivery system (MDDS) prevents degradation and remains the drug release in stomach or upper part of GIT for prolonged period of time, therefore the maximum drug release is maintained at desired site. After oral administration, are designed to prolong the gastric residence time, increase drug bioavailability and target the gastric infections. A mucoadhesive drug delivery system was developed using like mucoadhesive polymers and hydrocolloids, like hydroxypropyl methylcellulose (HPMC K100M), carbopol 934P and Sodium carboxy methyl cellulose (Sodium CMC). The prepared tablets were evaluated in terms of their physical characteristics, in vitro release, swelling index, mucoadhesive strength and scanning electron microscopy of optimized formulation. The formulations were optimized for different concentrations of HPMC, carbopol and Sodium CMC. The results of the in vitro release studies showed that the optimized formulation could sustain drug release for 12 h. The comparison of drug release profile of all formulations showed that formulations Fa1 which contains more amount of Carbopol 934p and fewer amounts of HPMC K100M and