Abstract
Objective: Since last decade drugs through skin has received great attention of many researchers. The aim of present study was designed to develop a suitable matrix type transdermal drug delivery system (TDDS) of Losartan potassium. Methods: Four transdermal patches formulations of Losartan potassium were prepared by using different polymers using blends of different polymers like polyvinylpyrrolidone K30 (PVP K30) and ethylcellulose (EC), hydroxypropyl methyl cellulose and chitosan. Physical studies including thickness, folding endurance moisture content, tensile strength and flatness were performed on all formulations. In-vitro diffusion study of 10 hrs was performed by means of Franz diffusion cell. Results: Thickness of four prepared patches lies in the range of 0.30 to 0.33 mm. Percent moisture content was found to be in the range of 2.56 to 3.44. The cumulative percent drug release after 10 hrs in between 38.41 to 80.41%. Stability study performed on selective batch, TP1 for 12 weeks at different temperature indicates stability of transdermal patches at room temperature. Conclusion:Present study concluded that Losartan potassium can be formulated into the transdermal matrix type patches to sustain its release characteristics. Polymeric composition of batch TP1 (PVP K30: Chitosan: 70:30) was found to be the best choice for manufacturing transdermal patches of Losartan potassium among the formulations studied. Peer Review History: Received 2 April 2017; Revised 12 May; Accepted 13 May, Available online 15 May 2017 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 8.0/10 Reviewer(s) detail: Asmaa Ahmed Mohamed Ahmed Khalifa, Pharos University, Alexandria, Egypt, asmaa.khalifa@pua.edu.eg Dr. Dalia Kamal Zaffar Ali, Modern University for technology and information, Egypt, dr.moda88@gmail.com Similar Articles: DEVELOPMENT AND EVALUATION OF MATRIX TYPE TRANSDERMAL PATCHES OF PIOGLITAZONE HYDROCHLORIDE
Highlights
MATERIALS AND METHODS Losartan potassium was obtained from Bond Chemical Industries Limited, Lagos, Polyvinylpyrrolidone K30 and HPMC K100 was received from Afrik Pharmaceuticals Limited, Nigeria
Folding Endurance Three Losartan potassium transdermal patches of each batch were taken for this study
Losartan potassium transdermal patches formulation potassium were prepared by using different polymers was studied using locally fabricated Franz diffusion i.e. polyvinylpyrrolidone K30 (PVP K30), EC, chitosan, HPMC in different ratio
Summary
Skin is an effective medium from which absorption of the drug takes place and enters into systematic circulation over a period of time[1]. Transdermal patches are designed to slowly deliver the active substance(s) through the intact skin, resulting in a prolonged and adequately constant systemic absorption rate, reduced number of doses and side effects of drug and improved therapeutic efficacy[3]. Losartan potassium is an orally active angiotensin-II receptor antagonist used in the treatment of hypertension due to mainly blockade of AT1 receptor[5]. It is readily absorbed from the gastrointestinal tract[6]. In present work Losartan potassium was selected for development and evaluation of matrix-type transdermal patches in order to improve its bioavailability and reduce frequency of administration
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
