Abstract
Recently, researchers have looked at the use of nanotechnology as a drug-delivery system for topical and transdermal applications. The transport of medications and active ingredients to the skin via formulations, including nanoparticles, is a subject of substantial contemporary interest. The present work is proposed to prepare the atorvastatin nanogels to promote wound healing in a diabetic animalmodel.Atorvastatin nanogels were prepared by precipitation polymerization technique using hydroxy propyl methacrylate as polymer. The drug and polymer were selected in ratios of 1:1, 1:2, 1:3, 1:4, 1:5, 1:6, 1:7 and 1:8. Additionally, the produced nanogel was evaluated in vivo and examined for its particle size, trapping effectiveness, and drug release in vitro. The particle size of the prepared various formulations (F1-F8) showed a size range of 68 to 80nm, and entrapment efficiency was seen to be in the range of 58.36-86.75%. The cumulative percentage of drug release was reported to be 61.96 to 73.76 percent over a period of 12hours during the in vitro drug release investigation, which was conducted using phosphate buffer at pH 7.4.The drug release followeda non-fiction mechanism of release kinetics. On the other hand, in vivo comparative study showed a complete wound healing effect for nanogels on the 11th day, whereas for conventional gel on the 15th day.This study indicates that nanogels formulation heals the diabetic wound completely at a faster rate, and also the drug atorvastatin also can be used for diabetic wound healing.
Published Version
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