Abstract

Pulsatile Drug Delivery System: an Approach of Medication according to Circadian RhythmAnamika Singh, Harikesh Dubey, Indu Shukla,Dharmchand. P. Singh

Highlights

  • The synchronization of drug delivery with circadian rhythms of a disease is called chronotherapeutics (Reinberg, 1991, 1983)

  • Chronotherapeutic drug delivery system is a system of choice for treating diseases showing circadian rhythms

  • Chronotherapeutic drug delivery system releases the drug at required time which prevents unwanted exposure of the patients to drugs by decreasing dosing frequency and reduces the cost of treatment

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Summary

Introduction

The synchronization of drug delivery with circadian rhythms of a disease is called chronotherapeutics (Reinberg, 1991, 1983). The synchronization of drug delivery with circadian rhythm of a disease can be done by administrating dissimilar. Nocturnal asthma has a very large impact on quality of life as nocturnal asthma causes awakening at night (Chen et al, 2007). The medication for nocturnal asthma should be given at a time when the lung function is worst i.e. to match circadian rhythm of asthma, this helps in prevention of unwanted exposure of patient to drugs. The majority of drugs that are used a days for chronotherapy of nocturnal asthma are delivered once at night to prevent acute asthma attacks which are caused by chronic inflammation of airways. The benefit of once-daily dosing is that it improves patient adherence and promotes self-management of asthma (Durrington et al, 2014)

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