Abstract
Aim Anacardium occidentale (AO) possess potent anti-diabetic properties, owing to its high phytochemicals content. This study attempted to maximize the efficacy of AO by encapsulating it in a solid lipid microparticle (SLMs) formulation. Method Leaves of AO were extracted with water and formulated into SLMs using a lipid matrix composed of P90H and Dika fat. Characterisation of the SLMs include morphology, particle size, pH, encapsulation efficiency percentage, in vitro release and anti-diabetic properties. Result SLMs were spherical with sizes ranging from 16.7 ± 0.8 µm to 40.12 ± 2.34 µm, and had a fairly stable pH over time. Highest drug entrapment was 87%. Batch A2 exhibited an even release of 89%, sustained over time, and a mean percentage reduction in glucose of 25.9% at 12 h after oral administration to study animals. Conclusion A. occidentale-loaded SLMs exhibited a good hypoglycemic effect and can be used in the management of diabetes.
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