Abstract
Aloe vera is most popular in treatment of dermatological disorder in case of burn, tan and wound healing. The study was designed for crude Aloe vera extract, development of oil in water (o/w) emulsion, preparation of gel base using Aloe vera extract and formulation of the emulgel for topical application. The formulation was prepared by using carbomer 940 as polymer and isopropyl alcohol as penetration enhancer. The pH and viscosity of the Aloe vera emulgel were noticed to be 6.8 and 750 centipoise (cps) respectively. The interaction study between phytochemicals and the excipients was carried out using Fourier transform infrared (FTIR) spectroscopy. UV spectrometric analysis of plant extract was carried out. Dynamic light scattering (DLS) was performed to determine the particle size distribution of oil globules in emulsion. Mean particle size (oil globules) was observed to be 481 nm. Zeta potential and polydispersity index (PDI) was recorded to be -13.2 mV and 0.6 respectively.
Highlights
Topical delivery is an important route for local and systemic treatment
The gel base was prepared by using carbomer 940 and Aloe vera extract
Average oil globule size (481 nm) of emulsion suggested that the preparation was nanoemulsion and polydispersity index (PDI) explained the uniformity of oil globules in nanoemulsion
Summary
Topical delivery is an important route for local and systemic treatment. Topical delivery is defined as the application of a formulation containing drug to the skin to directly treat cutaneous disorders (eg. acne) is used both in cosmetic and pharmaceutical preparations. Aloe vera leaves are formed by a thick epidermis covered with cuticle that can be differentiated into thinner walled cells forming parenchyma with large water storage tissue This cells containing a transparent mucilaginous jelly which is referred as Aloe vera gel. Aloe vera serves for numerous purposes is used both internally and externally for multiple functions It is widely used for treating various digestive and dermatological disorders. The study was designed for crude Aloe vera extract, development of oil in water (o/w) emulsion, preparation of gel base using Aloe vera extract and formulation of the emulgel for topical application. 50 ml crude clear Aloe vera extract was mixed uniformly by using magnetic stirrer and the plant extract was filtered through a Whatman filter paper. The prepared emulsion was mixed with the gel in 1:1 ratio with gentle stirring to obtain the Aloe vera emulgel [6]
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