Development and evaluation of xyloglucan matrix tablets containing naproxen

Abstract

The xyloglucan (XGL) matrix tablets containing naproxen were prepared by conventional wet granulation technique and evaluated for its drug release characteristics. Hardness of the tablets was found to be in the range of 5.0-7.0 kg/ cm2. The tablets showed 98.23-99.12% of the labeled amount of drug, indicating uniformity in drug content. The swelling index increased with the increase in concentration of XGL and with the addition of hydroxypropylmethyl cellulose (HPMC) in the matrices, whereas swelling index decreased with the addition of cellulose acetate phthalate (CAP) and ethyl cellulose (EC). The compaction pressure had no significant effect on the drug release. Increase in polymer content and increased initial drug loading resulted in decreased drug release from the tablets. Addition of HPMC, CAP, and EC to XGL tablets decreased the drug release, and release was extended over a period of 8 h. The mechanism of release from all the tablets deviated from Fickian mode. Key words: Drug release, matrix tablets, naproxen, xyloglucan