Abstract
Self nano-emulsifying system drug delivery system (SNEDDS) is promising for drugs of BCS class II. The objective of present study to develop self nano-emulsifying drug delivery system for Lipophillic drug Telmisartan (TEL) to enhance the oral bioavailability of poorly water-soluble drug. TEL is an angiotensin II receptor blocker (ARB) and antihypertensive drug. Screening of Surfactant, Co-surfactant is done by percent transmittance and is also observed for turbidity or phase separation visually. Pseudo ternary phase diagram are constructed to identify the self-emulsifying regions and also to establish the optimum concentration of oil, surfactant and co-surfactant. For prepared formulation further characterization studies are done. Various studies like FTIR, SEM, Particle size, zeta potential is carried out for prepared SNEDDS. Further they are formulated into tablets and evaluated. All the results obtained are found to be in limits. From the present study it is clear that SNEDDS can be formulated to improve the dissolution and oral bioavailability of poorly water-soluble drug Telmisartan. Keywords: Bioavailability; poor water solubility; self-nanoemulsifying drug delivery system; telmisartan.
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