Development and evaluation of Simvastatin based SNEDDS for treatment of Alzheimer’s disease

Abstract

AbstractBackgroundThe purpose of this research work to improve solubility and bioavailability of Simvastatin using self nano‐emulsifying drug delivery system (SNEDDS) for treatment the Alzheimer’s disease.MethodSelf emulsifying property of various oils including essential oils was evaluated with suitable surfactants and co‐surfactants. Validation of method for accuracy, repeatability, Interday and intraday precision, ruggedness, and robustness were within the acceptable limits. The liquid SNEDDS was prepared and optimized using ternary phase diagram, thermodynamic, centrifugation and cloud point studies.ResultThe globule size of optimized formulations was less than 200 nm which could be acceptable nanoemulsion size range. The mean droplet size, drug loading, PDI and zeta potential were found to be 141.0 nm, 92.22%, 0.23 and ‐10.13 mV and 153.5nm, 93.89%,0.41 and ‐11.7 mV and 164.26 nm, 95.26%, 0.41 and ‐10.66mV respectively. The best formulations were subjected to FESEM for surface morphology.ConclusionFormulation development, and evaluation of simvastatin loaded self nano‐emulsifying drug delivery system (SNEDDS) for treatment the Alzheimer’s disease were carried out.