Abstract
Acne is disorder of pilosebaceous unit, and generally characterized by formation of seborrhea, comedones, inflammatory lesions and presence of bacteria Propionibacterium acnes in the follicular canal and sebum production. Each of these factors provides a potential target for treatment. Propionibacterium acnes are the pharmacological target site of anti-acne drugs. methanolic extract was prepared and evaluated for antioxidant and antibacterial activity The aim of present study was to prepare herbal gel formulation containing methanolic extract of Rubia cordifolia on acne. Topical gel formulation was designed by using methanolic extract of roots and stems of Rubia cordifolia in varied concentrations. The gel was prepared by using carbopol 940(1%w/v), Rubia cordifolia Extract, ethanol, propylene glycol, methyl paraben, propyl paraben, EDTA disodium, tri-ethanolamine and required amount of distilled water The prepared gels were evaluated for physical appearance, pH, drug content, diffusion study, viscosity, antibacterial activity. Thus, it may be concluded that gel formulations were good antibacterial and antioxidant activity can be used in antiacne activity.
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