Development and evaluation of N-acetyl glucosamine-decorated vitamin-E-based micelles incorporating resveratrol for cancer therapy

Abstract

Treatment of cancerous cells like diseases underwent huge latest advancement scenario treatments with a molecular focus targeted therapy. However, non-specifically approaches through the pharmaceutical phytochemicals help a promising alternative approach for cancers. The present research study was seeking to aim at formulating the Resveratrol (RES) loaded Vitamin-E (Vit.E) micelles to improve their bioavailability and reduce toxicity. Resveratrol is a Phyto origin anticancer constituent, lipophilic in nature, with limited water solubility, resulting in poor oral bioavailability and consequently frequent dosing. Thin-film hydration (solvent casting) technique was employed in the building of RES-loaded Vit.E micelles. Prepared micelles are characterized for various parameters and the findings of in vitro evaluation studies revealed proposed micelles having the particle size of 243.4 (d. nm), polydispersity index (PDI) 0.330, zeta potential (−12.4 mV), percentage of entrapment efficiency (80.57% ± 1.06%), and percentage of drug loading (2.77 ± 1.23%), drug release in vitro (75.96%), haemolytic activity in vitro, and cytotoxicity studies in vitro. Furthermore, DSC and P-XRD analysis demonstrated that RES was effectively encapsulated within Vit.E micelles. Drug release studies revealed that dissolution of drug was improved because of loading into micelles and Transmission electron microscopy (TEM) imaging study confirmed spherically of micelles.