Abstract
The muscarinic cholinergic receptor ligands N-[ 11C]ethyl-4-piperidyl benzilate (4-EPB) and N-[ 11C]propyl-4-piperidyl benzilate (4-PPB) were developed and evaluated in comparison with N-[ 11C]methyl-4-piperidyl benzilate (4-MPB) in the conscious monkey brain using positron emission tomography (PET). Time-activity curves of [ 11C]4-EPB, unlike [ 11C]4-MPB, showed peaks within 91 min in regions rich in muscarinic receptors. [ 11C]4-PPB showed no specific binding even in the regions rich in these receptors. These observation demonstrated that increases in [ 11C]alkyl chain length could alter the kinetic properties of receptor ligands for PET.
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