Abstract
Fenoprofen belongs to Biopharmaceutical Classification System (BCS) class II drugs which are poorly soluble in water. The objective of present research work was to prepare fast dissolving tablets of fenoprofen using varying concentrations of three different sublimating agents to improve the dissolution rate. Seven formulations were prepared containing different concentrations of camphor, ammonium bicarbonate and thymol as sublimating agent along with primogel as a superdisintegrant. Tablets were manufactured by direct compression method. The prepared tablets were evaluated for pre-compression and post-compression parameters result, for all formulations result was within official limits. DSC studies revealed that there were no interactions between the drug and the excipients used. From in vitro drug release studies the dissolution studies, cumulative percentage of drug release versus time was evaluated. It also reflects that the formulations F4 and F15 containing 45 mg and 67.5 mg of thymol respectively showed fast drug release of 100.00% and 99.56 % respectively in 30 minutes as compared with formulations containing other sublimating agents. Among all the formulations, F6 and F7 tablets showed complete drug release within 30 minutes and rapid dissolution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
