Abstract
Purpose: To fabricate ketoprofen transdermal patches (KTPs) using an acrylic pressure-sensitive adhesive (PSA) polymer.Methods: KTPs were prepared using solvent casting method. The influence of the amount of PSA, drug content, and terpenes as penetration enhancers on the characteristics of the patch, namely, thickness, W/A ratio, and adhesiveness and in vitro skin permeation, were investigated. Scanning electron microscope (SEM) and differential scanning calorimetry (DSC) studies were also performed on the patches. The physical and chemical stability of KTPs after storage at 40 oC, and 75 %RH for 1 month was also evaluated.Results: DSC thermograms demonstrate that the drug was dispersed molecularly in the polymer in all the formulations. Increase in PSA content increased the W/A ratio and adhesiveness of KTPs. Ketoprofen release from the transdermal patches followed the Higuchi diffusion model. Ketoprofen flux increased with increase in the ketoprofen content of the adhesive matrix. Inclusion of terpenes in the patch formulations significantly increased the permeation of ketoprofen through the skin, with enhancement ratio (ER) ranging from 1.4 to 2.6.Conclusion: KTPs formulated with acrylic pressure-sensitive adhesive and incorporating terpenes as permeation enhancers demonstrated suitable characteristics for transdermal delivery of ketoprofen.Keywords: Ketoprofen, Transdermal patch, Skin permeation, Acrylic matrix, Terpenes, Pressuresensitive adhesive.
Highlights
Ketoprofen (KP) is a non-steroidal antiinflammatory and analgesic drug
Various systems for the preparation of ketoprofen transdermal drug delivery devices have been reported in the literature [6,7,8], better systems that would result in improved patch stability and high skin permeation of KP are still required
The objective of this work was to evaluate the effect of formulation factors, such polymer and drug content, and penetration enhancers, on the physicochemical properties and skin permeation of drug, KPT formulated with pressure-sensitive adhesive
Summary
Ketoprofen (KP) is a non-steroidal antiinflammatory and analgesic drug. One promising method to reduce this adverse effect is to deliver the drug through the skin. Some ketoprofen transdermal patches (KTPs) have been developed by previous researchers. Adachi et al [7] found that a polymer matrix made up of styrene-isoprene-styrene (SIS) is an excellent material for the preparation of KTPs with good adhesiveness and skin permeation. Various systems for the preparation of ketoprofen transdermal drug delivery devices have been reported in the literature [6,7,8], better systems that would result in improved patch stability and high skin permeation of KP are still required
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