Development and Evaluation of Floating Bilayer Tablet Containing Combination of Oxethazine and Cefixime Trihydrate

Abstract

Aim The objective of present work was to formulate and evaluate bilayer tablets of Oxethazine and Cefixime trihydrate developed by direct compression method for effectively treating gastric ulcer and H. pylori infection.Methods The tablets were prepared having immediate release layer of Oxethazine and sustained release layer of Cefixime trihydrate. Sodium starch glycolate was used as super disintegrant for immediate release layer. The bilayer tablets were prepared by direct compression method using HPMC K100 and natural polymers like xanthan gum guar gum karaya gum which release the drug for 12 hours. Pre-compression parameters post-compression parameters and physical characteristics were evaluated for prepared formulations.Results The release of the Oxethazine from the immediate release layer was found to be 94.6plusmn0.02 in 30 minutes. The release of Cefixime trihydrate for the sustained release floating layer was found to be 99.88plusmn0.06 in 12 hours. The data obtained from in vitro release were fitted into the various kinetic models Zero Order Higuchi First Order and Kors MeyerndashPepparsquos Model.Conclusion The bilayer tablets developed offer both immediate release of Oxethazine and sustained release of Cefixime trihydrate. This suggests their potential as a viable option for treating gastric ulcers and H. pylori infections using an innovative dosage form.