Development and Evaluation of Emulgel Formulation of Diclofenac Sodium utilizing Lipidium sativum as a Gelling Agent

Abstract

Emulgels have gained recognition as an effective method for delivering non-polar drugs. The primary goal of our current research is to investigate the potential of Lepidium sativum seed mucilage as a gelling agent in this context. To enhance drug penetration, we have incorporated clove oil, oleic acid, and methyl salicylate. An emulsion was formulated and subsequently integrated into the gel base. Our research encompassed a series of studies, including rheological assessments, spreading coefficient evaluations, investigations into skin irritancy, and other relevant tests. Furthermore, we conducted drug content analysis, in-vitro release and permeation studies, and stability assessments. In our in-vitro investigations, it was observed that formulation E6 exhibited the highest drug release within a span of 180 minutes. Comparative analyses were conducted, pitting formulations E4, E5, and E6 against a commercially available emulgel preparation. As a result of our findings, it is evident that an emulgel employing L. sativum mucilage can effectively function as a gelling agent in a topical drug delivery system.