Abstract
Camptothecin-loaded nanoemulsion (CPT/NE), sodium alginate, carbomer and calcium chloride were chosen to prepare camptothecin-loaded nanoemulsion / hydrogel (CPT/NE/HG) pellets. The optimal formulation of CPT/NE/HG pellets was composed of a mixture of the CPT/NE to hydrogel (1:1, w/w) followed by solidification with 15.0% CaCl2 solution, and the hydrogel consisted of a mass ratio of 1:1 of sodium alginate (1.92 %, w/v) and carbomer 934P (2.20 %, w/v). The reconstitution of pellets showed that there were nanoemulsions, microemulsions or mixed micelles existed together in simulated colonic fluid (SCF). The camptothecin releasing from the CPT/NE/HG pellets was less than 20 % in simulated gastric fluid while more than 40% loaded camptothecin released in SCF, and the release process was conformed to be first-order kinetics. The in vivo imaging indicated that the CPT/NE/HG pellets were firstly aggregated in the stomach while the most pellets were destructed after reaching the colon. The inhibitory effect of CPT/NE/HG pellets on LoVo cell growth was significantly stronger than that of CPT solution.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
