Abstract
The present research article represents the formulation and evaluation of buccoadhessive film of ropinirole hydrochloride. This drug is an oral non-ergoline dopamine agonist with the greater affinity at D3 receptor. This drug having low molecular weight (296.84 g/mol), and short biological half-life (4-6 hrs) which necessitates for multiple dosing for maintaining therapeutic effect throughout the day. Moreover, drug is metabolized in liver forming several inactive metabolites which decrease it oral bioavailability upto 50% making it a suitable candidate for administration of drug through buccal mucosa. Buccal films of ropinirole hydrochloride were prepared using various polymers (HPMC, EC, PVA and Carbopol) by solvent casting method using propylene glycol as plasticizer. These films were evaluated for various parameter such as appearance, surface texture, weight uniformity, thickness, folding endurance, surface pH, drug content and swelling index. All the formulations were subjected to in vitro drug release study which were carried out using egg membrane as semi permeable membrane.
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