Development and evaluation of anti-hemorrhoid alum suppositories

Abstract

Rectal suppositories of Alum were prepared using different bases and polymers like Shea butter, and PEG-4000 and its effect on the In-vitro release of Alum was studied. The Agar-based suppositories were non-disintegrating, and non-dissolving, whereas PEG-4000 based were disintegrating and dissolving. The Fusion Method and Trituration Method were used for the formulation of the suppositories. In-vitro tests were carried out on the formulations. All the formulated suppositories were tested for several physical parameters namely weight variation, drug content of suppositories, disintegration test, and dissolution rate. The PEG-4000 and Shea butter suppositories were of macro melting range, disintegration, and liquefaction time.