Abstract
Objective: Albendazole is a benzimidazole carbamate broad spectrum oral anthelmetic drug. It is poorly water soluble and it undergoes extensive metabolism in the intestine and liver. Objective of present study was to prepare and evaluate microcapsule of Albendazole for colonic delivery. Methods: Six batches of Albendazole microcapsules were prepared using different concentration of polymers like Eudragit RS-100, chitosan, HPMC by solvent evaporation method. The microcapsules were then evaluated for micromeritic properties, percentage yield, incorporation efficiency, drug content. In vitro dissolution profile of each formulation was determined by employing USP XXIII rotating basket method. Results: The drug content was found to be very high in all formulations, incorporation efficiency was found to be good in all formulations. Highest incorporation efficiency 96.48 % was found in batch of MC6. Maximum drug release was shown by microcapsules formulation of batch MC6 (90.18%) Conclusion: Study concludes that Albendazole microcapsules may prove to be potential candidate for safe and effective sustained drug delivery. Peer Review History: Received 2 April 2017; Revised 6 May; Accepted 10 May, Available online 15 May 2017 UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency. Received file: Reviewer's Comments: Average Peer review marks at initial stage: 3.5/10 Average Peer review marks at publication stage: 7.5/10 Reviewer(s) detail: Dr. Mohamed Salama, Modern University for Technology & Information, Egypt, salama47@yahoo.com Dr. Hasniza Zaman Huri, University of Malaya Medical Centre, Kuala Lumpur, hasnizazh@ummc.edu.my Similar Articles: COLON SPECIFIC DRUG DELIVERY SYSTEMS: CURRENT TRENDS AND APPROACHES FORMULATION AND EVALUATION OF COLON TARGETED MATRIX TABLETS CONTAINING EXTRACT OF SOLENOSTEMMA ARGEL (HARGEL)
Highlights
Onyeka Ifeanyi Peter, Ukwe Chioma Ifeoma Department of Pharmacognosy and Traditional Medicine, Nnamdi Azikiwe University Awka, Nigeria
The incorporation efficiency was found to be good in all formulations
Entrapment efficiency increase with increase in the polymer concentration from the results it can be inferred that there is a proper distribution of Albendazole in the microcapsules and the deviation is within the acceptable limits
Summary
Development and evaluation of Albendazole microcapsule for colonic drug delivery system. The colon is attracting inter est as a site where poorly absorbed drug molecule may have an improved bioavailability[1]. The colon has a long retention time and appears highly responsive to agents that enhance the absorption of poorly absorbed drugs. In present study microcapsules of Albendazole were formulated for colonic drug delivery to avoid side effects associated with albendazole therapy and to improve pharmacological
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