Abstract
In the present work, a dual-drug-loaded soy lecithin liposomal system was developed by coencapsulation of Letrozole (LET) with Paclitaxel (PTX) to improve the efficacy in breast cancer therapy. Liposomes were synthesized by the thin film layer hydration. To sufficiently evaluate the characteristics of these liposomes, the particle size, zeta potential, morphology, drug encapsulation, in vitro drug release, and cytotoxicity were ascertained. Results showed promisingly anticancer potentials, as the following parameters indicated: nanosize diameter (around 193 nm) and negative surface charge. Data collected from the coloaded drug liposomes showed suitable encapsulation efficiency (50.56% for PTX and 31.13% for LET). Controlled and sustained releases were achieved up to 72 h for both the loaded drugs following the diffusion mechanism. In addition, the in vitro cytotoxicity study on the human breast cancer cell line (MCF-7) given the dual-drug-loaded liposome showed greater inhibition of cell growth than the single drug. Consequently, LET and PTX coloaded liposomes made from soy lecithin are expected to be an ingenious drug-delivery system for combination chemotherapy.
Highlights
Breast cancer therapy using oestrogen-targeted drugs is one of the most successful anticancer strategies to date
Researchers have currently focused on LET combination therapies, with chemotherapy, to take advantage of therapies using multiple drugs including coordinately distributed drugs to specific sites, reduce toxicity, and increase efficacy of drugs, as well as slow the rate of developing drug resistance, in order to advance in the full potentials of chemodrug treatments [8]
By preventing the cells from dividing and replicating and causing the death of the cells in various proposed mechanisms, PTX in combination with LET is expected to destroy any of the remaining cancer cells, which are left uninhibited during the developing of LET [9,10,11]
Summary
Breast cancer therapy using oestrogen-targeted drugs is one of the most successful anticancer strategies to date. Regarding its overall effects on human health, LET was reported to possess potential efficacy that could be enhanced by advancing in combination with other chemotherapeutic agents [4,5,6,7]. Researchers have currently focused on LET combination therapies, with chemotherapy, to take advantage of therapies using multiple drugs including coordinately distributed drugs to specific sites, reduce toxicity, and increase efficacy of drugs, as well as slow the rate of developing drug resistance, in order to advance in the full potentials of chemodrug treatments [8]. Chen et al have published their study in AntiCancer Drugs, reporting that exemestane, one of the aromatase inhibitors (AIs), could combine with Paclitaxel for the treatment of aromatase-positive gynecological cancer [9]
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