Abstract
Two polysaccharides (cellulose and chitosan) and polyurethane dissolved in 1-ethyl-3-methylimidazolium chloride represented the matrix for the obtainment of new composite formulations comprised of lignin, ferrite–lignin hybrid and ketoconazole. The mechanical performances (Young’s modulus and compressive strength) increased with the filler addition. The nature of the filler used in the studied formulations influenced both bioadhesion and mucoadhesion parameters. It was found that the incorporation of lignin and ferrite–lignin hybrid into the matrix has influenced the in vitro rate of ketoconazole release, which is described by the Korsmeyer–Peppas model. All materials exhibited activity against Gram positive (Staphylococcus aureus ATCC 25923) and Gram negative (Escherichia coli ATCC 25922) bacteria.
Highlights
Synthesis of multifunctional materials has received much attention in the last decades due to their improved attributes
Two polysaccharides and polyurethane dissolved in 1-ethyl-3methylimidazolium chloride represented the matrix for the obtainment of new composite formulations comprised of lignin, ferrite–lignin hybrid and ketoconazole
The Young’s modulus and compressive strength increased with the addition of lignin (Cel-CS-PU-L), lignin hybrid (Cel-CS-PU-LH) or ketoconazole (Cel-CS-PU-KK) filler (Figure 3C,D)
Summary
Synthesis of multifunctional materials has received much attention in the last decades due to their improved attributes. In spite of their lower properties as compared to synthetic ones, the natural polymers represent one of the most promising options towards a green and sustainable future. Cellulose and chitin are most abundant natural carbohydrate polymers, having a high degradable and recyclable potential. Cellulose (Cel) is the major component of biomass. It presents excellent mechanical and thermal resistance and is widely used for the production of papers, fibers, textile fabrics, explosives, plastics or composite materials. Cellulose is a linear polymer consisting of carbon, hydrogen and oxygen in the form of β-d-glucopyranose units linked by β-1,4-glycosidic bonds
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