Abstract
Every year millions of new cases of various types of cancers are diagnosed, leading to an alarming rate of fatalities. Mitoxantrone is an anthracenedione antineoplastic agent which is used in the treatment of various types of cancer, mostly acute myeloid leukemia and prostate cancer. In spite of its therapeutic applications, it possesses numerous limitations and side effects including specific targeting and systemic toxicity. Sodium alginate is a biodegradable, mucoadhesive and biocompatible polymer commonly used in drug delivery applications. Glutaraldehyde is a saturated dialdehyde and is used as a polymer cross linker. In this study, mitoxantrone-loaded glutaraldehyde-sodium alginate nanoparticles were developed by ionic gelation method and characterized (determination of particle size, drug entrapment efficiency, drug release and its kinetics) for the delivery of anticancer drugs. The nanoparticles mean particle size was found to be within the acceptable range. The entrapment efficiency was also on the higher side with sustained drug release. The findings of this study reveal promising potential of delivery system and project the way forward for further in vitro and in vivo investigations.
Highlights
Cancer is a deadly set of diseases which involves uncontrolled growth of cells with the possibility of invading or spreading across the body [1,2]
3.1 Analysis of Particle Size nanoparticles were found to be in the range of 320 - 467 nm
The readings were recorded on nicomp particle size analyzer (Table 2)
Summary
Cancer is a deadly set of diseases which involves uncontrolled growth of cells with the possibility of invading or spreading across the body [1,2]. Chemotherapeutics triggers adjacent normal cells to discharge some growth factors or cytokines which stimulate tumor cells growth eventually resulting in drug resistance [8] This chemotherapy resistance [9,10] leads to the over-expression of multidrug resistance gene (P-gp) and support the efflux of drug to reduce the drug concentration in cells, inadequate to reach the lethal dose to kill cancer cells. These unwanted side effects of mitoxantrone can possibly be addressed by using nanoparticles. Past two decades have seen the discovery of a range of biodegradable polymers showing anticipated controlled, sustained, and selective targeting effect while simultaneously keeping the concentration of drug inside the therapeutic window
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