Abstract
Chitosan (CS) is a natural polymer widely used in the development of various materials. Chemical modifications to its structure guarantee an improvement in its physicochemical and bioactive properties. Therefore, in this study, sulfation of chitosan (CS-S) and incorporation of essential oils (EOs) of Syzygium aromaticum and Cinnamomum ssp. were carried out, with the aim of obtaining a material to be applied in the control of dermatophytosis caused by the fungus Microsporum canis. The material obtained was characterized using FTIR, 13C SSNMR, TGA-MS and SEM techniques. The presence of sulfate groups causes the material to have greater solubility in aqueous media (4.18 ± 1.1 g L−1) compared to Chitosan (0.70 ± 0.6 g L−1). Incorporation efficiency (IE) demonstrated that CS-S has the ability to incorporate EOs with values close to 21 % (W/W). Dynamic light scattering (DLS) studies showed that CS-S particles had a manometric size (CS-S-EOC 960.6 ± 161.2 nm and CS-S-EOS 414.1 ± 118.0 nm), when in aqueous medium, after EO incorporation. The antifungal potential was evaluated for CS-S-EOC and CS-S-EOS, with values of 59.67 % and 64.93 %, respectively, demonstrating inhibition potential on the mycelial growth of the fungus Microsporum canis.
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