Abstract
Buccal films containing two vitamins, i.e., thiamine hydrochloride (THCl) and nicotinic acid (NA), were fabricated via two-dimensional (2D) inkjet printing. For the preparation of buccal films, solubility studies and rheological evaluations were conducted in distilled water and propylene-glycol (PG) as main solvent and viscosity/surface tension modifier, respectively. The increased solubility in the solvents’ mixture indicated that manufacturing of several doses of the THCl and NA is achievable. Various doses were deposited onto sugar-sheet substrates, by increasing the number of printing passes. The physiochemical characterization (SEM, DSC, FTIR) revealed that inkjet printing does not affect the solid state of the matrix. Water uptake studies were conducted, to compare the different vitamin-loaded formulations. The in vitro release studies indicated the burst release of both vitamins within 10 min, a preferable feature for buccal administration. The in vitro permeation studies indicated that higher concentrations of the vitamins onto the sugar sheet improved the in vitro permeation performance of printed formulations.
Highlights
In the last decade, printing technologies have gained popularity in the pharmaceutical field
Regarding thiamine hydrochloride (THCl), the solubility testing in water and in PG was terminated at a content of 198 mg/mL and 100 mg/mL, respectively, due to the observed increase in viscosity of the solutions, the solvents were capable of dissolving further amounts of the vitamin
Buccal films of B-complex vitamins were developed via 2D printing technology, a new and safe way for producing drug or vitamin loaded formulations
Summary
In the last decade, printing technologies have gained popularity in the pharmaceutical field. In particular, is a non-contact method for alternative manufacturing of orally delivered formulations [1]. Drop-on-demand thermal inkjet printing provides a number of advantages in pharmaceutical technology. It facilitates the deposition of small amounts of liquids onto edible substrates, while the formulation is based on predesigned digital patterns [2]. The procedure is based on the generation of thermal pulses and the subsequent formation of a vapor bubble which expands and forces the liquid ink through the nozzle of the printer’s cartridge. A liquid droplet is formed directly and sprayed onto the substrate [3]
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