Abstract
Development and characterization of human iPSC-derived myofibroblast-like cells
Highlights
Introduction αSmooth muscle actin-positive myofibroblasts are important for tissue regeneration
This study compared renal-resident fibroblasts, which are derived from neural crest cells (NCCs) [6] and myofibroblastlike cells, which are obtained from human induced pluripotent stem cell-derived neural crest like cells (NCLCs) [7]
Of-human induced pluripotent stem cells (hiPSCs)-derived myofibroblast-like cells possess the same characteristics as human primary renal fibroblasts: Renal fibroblasts/ myofibroblasts originate from NCCs [14], and protocols have been developed to generate myofibroblast-like cells from hiPSCs [12]
Summary
Smooth muscle actin (αSMA)-positive myofibroblasts are important for tissue regeneration. Tissue-resident fibroblasts and Mesenchymal Stem Cells (MSCs) differentiate into myofibroblasts to repair tissues [1]. Myofibroblasts are observed in pathological conditions, such as fibrosis [2]. ΑSMA-positive myofibroblasts are a major cause of fibrosis, and their level increases with fibrotic disease development [3]. The origin of tissue-resident fibroblasts differs among tissues. It was reported that lung-resident fibroblasts are derived from hematopoietic stem cells, while hepatic stellate cells (liver-resident fibroblasts) are derived from MSCs [5]. This study compared renal-resident fibroblasts, which are derived from neural crest cells (NCCs) [6] and myofibroblastlike cells, which are obtained from human induced pluripotent stem cell (hiPSC)-derived neural crest like cells (NCLCs) [7]
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