Abstract
The study’s objective was to develop an optimized gastro retentive drug delivery system of olmesartan medoxomil. The tablets were formulated by direct compression using HPMC K15M, HPMC K4M, Xanthan Gum, and PVP K30. Sodium bicarbonate was used as the gas generating agent to reduce the floating lag time. The drug-polymer interaction was evaluated by fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) study. The FTIR and DSC study indicated the lack of drugpolymer interaction. The formulated tablets were evaluated for hardness, weight variation, thickness, floating capacity, swelling index, drug content, in vitro dissolution study. The formulations were following nonfickian (anomalous) diffusion as the release mechanism from all the floating tablets prepared with various polymers.
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