Development and Characterization of Eudragit Rl100 Nanoparticle Loaded Duloxetine Hydrochloride Gel for Transdermal Drug Delivery

Abstract

Purpose: The study sought to examine the feasibility of transdermal delivery of duloxetine hydrochloride from a nano-gel and in-vitro assessment of the gel to demonstrate improved solubility and drug absorption from in-vitro permeation studies using rat skin. Materials and Methods: Six formulas of amorphous duloxetine hydrochloride-loaded nanoparticle (NP) using eudragit RL 100 and Tween 80 as a stabilizer in the different ratios of ethanol by the solvent antisolvent technique. The physicochemical critiques of the amorphous duloxetine hydrochloride-loaded NP have completed the best formulation, NPF6, fourier-transform infrared (FTIR) spectroscopy, differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), particle size, and surface morphology analysis. The nano gel on produced using NPF6 in hydroxypropyl methylcellulose (HPMC) and carbopol glycol 934 gelling solutions. Investigated the gel’s mechanical and rheological characteristics and in-vitro permeation. Results: The chosen solvent-antisolvent precipitation technique might produce NP with desirable physicochemical characteristics. The particle size of the nanoparticle’s two factors is regulated by solvent: antisolvent surfactant content and ratio. According to the findings of the FTIR investigation, the medication and excipients were compatible. The scanning electron microscope (SEM) investigation reveals the development of distinct asymmetric NPs. A comparative learning process and statistical analysis discovered that the best thermosensitive nanogel of amorphized duloxetine hydrochloride NPs with higher bioavailability features was carbopol glycol 934 gel. Conclusion: As an outcome, the previously described in-vitro assessment of in-place nano gel put an example of the invention’s latent for increased solubility, patient compliance, and transdermal distribution of duloxetine hydrochloride.