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Abstract
Objective: This study aimed to develop the nanostructured lipid carriers (NLCs) for repairing the hair split-end and to compare the influence of NLCs charges on hair binding effects.
 Methods: NLCs was prepared by a high-pressure homogenization technique. The difference solid lipids were selected to obtain the negatively charged NLCs (N-NLCs) and positively charged NLCs (P-NLCs). The physical characterizations of both NLCs were examined. The NLCs cream was prepared by mixing NLCs into a cream base. Then, the hair split-end binding effects of the NLCs cream were assessed. The physical stability of both NLCs were investigated by kept at room temperature for 6 mo.
 Results: The N-NLCs and P-NLCs were successfully prepared with a zeta potential of -44.4 mV and 32.3 mV, respectively. They were a spherical shape with a similar mean size of ~150-160 nm. The hair split-end evaluation showed that both NLCs illustrated similar hair split-end binding time of more than 3 d, suggesting no extra benefit from the positively charged of P-NLCs. On the contrary, the cream base and commercial product showed a short binding time of <8 h. Furthermore, after 6-mo storage, N-NLCs demonstrated good physical stability without particle aggregation, while P-NLCs exhibited a phase separation.
 Conclusion: The developed NLCs is a novel alternative for the leave-on product, which would be highly benefits for hair split-end repairing.
Highlights
Most hair damages occur inevitably by chemical treatments such as waving, relaxing, bleaching, and coloring process leading to hair fuzzy
The TEM micrographs of N-nanostructured lipid carriers (NLCs) and positively charged NLCs (P-NLCs) exhibited spherical shape and showed a similar particle size to those obtained by dynamic light scattering (DLS), as shown in fig. 1
negatively charged NLCs (N-NLCs) and P-NLCs were successfully prepared by a high-pressure homogenization technique with a zeta potential of ~-44 mV and ~33 mV respectively
Summary
Most hair damages occur inevitably by chemical treatments such as waving, relaxing, bleaching, and coloring process leading to hair fuzzy. These cosmetic practices could damage the hair protein structure from the outermost layer as cuticle to the cortex, resulting in the loss of hair mechanical strength and formation of split-ends [1,2,3]. The mechanical process of heat styling and combing could lead to more severe longitudinal split-end, which resulting in hair breakage [4] These effects are undesirable because the good appearance of hair is related to selfconfidence and personality for the human being. The use of hair care product for temporarily repairing the hair split-end is widely practiced [5]
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