Abstract
TThe rapid growth in molecular genetics and the development of mouse models of human diseases have led to significant interest in in vivo small animal-imaging. Several instrumentation approaches [Weber, 1994, Tsui, 2001, McElroy, 2002, Peterson, 2002 ]have been utilized to develop high-resolution animal SPECT for functional small-animal imaging. Compact modular cameras based on pixelated crystal and position sensitive photomultiplier tube (PSPMT)are a low-cost alternative to conventional gamma cameras for use in pinhole SPECT systems with high detection efficiency and resolution [Qi,2003 ].We have developed a compact, high-resolution microSPECT system in our laboratory for small-animal imaging.Our approach was to use a dedicated mini camera with pinhole collimator. The modular camera was based on a pixelated NaI(Tl)crystal array and a single 5 Hamamatsu PSPMT. The system performance was characterized using small point source. The system spatial resolution and sensitivity were measured. High-resolution phantom and in vivo mouse imaging were performed to demonstrate the system capability.
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